Carnosine Metabolism in Diet-Induced Obesity

DexaScan images of mice fed high fat diet for 6 weeks

Recent studies demonstrate that the dipeptide carnosine is depleted in the skeletal muscle of patients with T2D and that carnosine feeding decreases diet-induced obesity. Our initial studies show that high fat feeding in mice decreases carnosine levels and that restoration of these levels by carnosine supplementation restricts weight gain, increases energy expenditure, insulin senstivity and glucose tolerance. Based on these observations, we propose that chronic carnosine deficiency decreases energy expenditure and antioxidant capacity of the muscle, resulting in insulin resistance and oxidative stress

Process to test hypothesis:

  • Elucidate the mechanism of carnosine depletion in obesity;
  • Test whether carnosine supplementation prevents or reverses obesity and its metabolic consequences; and
  • Investigate the mechanism by which carnosine regulates adiposity and insulin sensitivity.

The findings of this project could lead to the development of a novel and validated anti-obesity strategy that could also prevent or reverse diet-induced insulin resistance.

Principal Investigator

Shahid Pervez Baba, PhD />
<h3>Shahid Pervez Baba, Ph.D.</h3>
<p>Assistant Professor of Medicine<br /><a href=

Shahid Pervez Baba, Ph.D.

Assistant Professor of Medicine
E-mail Dr. Baba

Education:
Ph.D., biochemistry, Aligarh Muslim University, India.
Fellowship: Philip Morris External Research Program.

Research Focus:

  • Examining the metabolic role of aldo-keto reductases (AKRs), in metabolizing different advanced glycation end products (AGEs) precursors and advanced lipoxidation products (ALEs).
  • Investigating the mechanisms of endogenously generated quenchers in quenching AGEs and ALEs.

Related publications:
Acrolein inhalation prevents VEGF-induced mobilization of Flk-1+/Sca-1+ cells in mice

Reductive metabolism of AGE precursors: a metabolic route for preventing AGE accumulation in cardiovascular tissue

U of L receives $600,000 grant to research heart health