Carnosine Metabolism in Diet-Induced Obesity
Recent studies demonstrate that the dipeptide carnosine is depleted in the skeletal muscle of patients with T2D and that carnosine feeding decreases diet-induced obesity. Our initial studies show that high fat feeding in mice decreases carnosine levels and that restoration of these levels by carnosine supplementation restricts weight gain, increases energy expenditure, insulin senstivity and glucose tolerance. Based on these observations, we propose that chronic carnosine deficiency decreases energy expenditure and antioxidant capacity of the muscle, resulting in insulin resistance and oxidative stress
Process to test hypothesis:
- Elucidate the mechanism of carnosine depletion in obesity;
- Test whether carnosine supplementation prevents or reverses obesity and its metabolic consequences; and
- Investigate the mechanism by which carnosine regulates adiposity and insulin sensitivity.
The findings of this project could lead to the development of a novel and validated anti-obesity strategy that could also prevent or reverse diet-induced insulin resistance.
Shahid Pervez Baba, Ph.D.
Assistant Professor of Medicine
E-mail Dr. Baba
Ph.D., biochemistry, Aligarh Muslim University, India.
Fellowship: Philip Morris External Research Program.
- Examining the metabolic role of aldo-keto reductases (AKRs), in metabolizing different advanced glycation end products (AGEs) precursors and advanced lipoxidation products (ALEs).
- Investigating the mechanisms of endogenously generated quenchers in quenching AGEs and ALEs.