Local Regulation of Calcium Influx in the Vasculature During Hyperglycemia


calcium influx graphsDiabetes mellitus and associated hyperglycemia leads to elevation of calcium in vascular smooth muscle, contributing to the development of cardiovascular complications.

Our work has discovered altered mechanisms of membrane excitability and direct stimulation of Ca2+-permeable ion channels that may act in concert in diabetic patients to enhance vasoconstriction, ultimately limiting blood flow and raising vascular resistance.

Based on previous observations, we are investigating the contribution of intracellular scaffolding proteins, via anchoring enzymes to specific ion channel substrates, in modulating the electrophysiological profile of the cell in response to specific metabolic abnormalities that are associated with diabetes.

This research has the potential to validate previously unidentified targets and establish novel platforms upon which improved therapeutics for the treatment of cardiovascular diseases are developed.

Related Publications



Principal Investigator

Matthew Nystoriak

Matthew Nystoriak, Ph.D.

Assistant Professor of Medicine

Education

  • Ph.D.: Pharmacology, University of Vermont Medical School, Burlington, VT

  • Postdoc: Physiology and Biophysics, University of Washington, Seattle, WA; Pharmacology, University of California, Davis, Davis, CA

Research Focus

  • Cellular and molecular mechanisms underlying altered regulation of membrane potential and Ca2+ signaling in the vasculature during diabetes

  • Metabolic regulation of cardiovascular ion channel activity

  • Role of intracellular scaffolding proteins in blood flow and blood pressure regulation during health and disease