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David A. Scott

Name: David A. Scott

Titles: (1) Associate Professor, Oral Health and Rehabilitation, Division of Oral Health and Systemic Disease; (2) Associate Professor, Microbiology and Immunology; (3) Associate Professor, Pharmacology and Toxicology; (4) Faculty Member, James Graham Brown Cancer Centre.

Position: Director, Oral Biology Graduate Program

Phone: +1-502-852-8905 (Office, 211-D); +1-502-852-5531(Lab, 211-C)

E-mail: dascot07@louisville.edu

Background
Dr. Scott completed his B.Sc. degree in Microbiology at Heriot-Watt University, Edinburgh Scotland in 1987 and, as a N.A.T.O. Fellow, obtained his Ph.D. in Microbiology and Immunology from McGill University, Montréal, Québec in 1997. He subsequently was a Research Fellow in the Department of Dental Clinical Research at King’s College London under the supervision of Drs. Richard Palmer and Ron Wilson. David moved to the University of Louisville after 4 years as an Associate Professor in the oldest Oral Biology department in the world at the University of Manitoba. He is a member of the editorial board of Tobacco Induced Diseases and the Open Inflammation Journal and is a frequent reviewer for multiple international scientific journals and several funding bodies, including NIH, AIBS, and CIHR. Dr. Scott is also an Honorary Member of the Delphi Society and the Omicron Kappa Upsilon Society.

Research Interests and Current Projects

  • Dr. Scott’s has received recent funding from NIH, CDC, CIHR, NSERC and the University of Louisville to pursue the following projects;
  • Tobacco-induced alterations to microbial-associated molecular patterns of Porphyromonas gingivalis
  • Tobacco-induced alterations to innate-pathogen interactions
  • Tobacco alkaloid amplification of endogenous anti-inflammatory pathways
  • Identification of gingivitis- and periodontitis-specific infrared molecular signatures

 

Teaching Activities

  • Undergraduate
  • SUHD 800-01: Correlated Sciences (Course Director)
  • IDSC 821-34: Pathomedicine (Lecturer)
  • Bio 390: Preview to Dentistry (Lecturer)


Graduate

  • OBIO 606: Seminars in Oral Biology (Course Director)
  • OBIO 600: Introduction to Oral Immunology (Lecturer)
  • OBIO 619: Oral Biology Research (Course Director, titular)
  • OBIO 620: Oral Biology Thesis (Course Director, titular)
  • One Ph.D student
  • One M.Sc. student
  • One Post-doctoral fellow


Continuing Education

  • The role of the dental professional in smoking cessation,  ULSD CME/CDE/CNE course
  • Tobacco smoking and oral health in men, Kentucky State Legislature CE program


Service
National and International

  • International Society for the Prevention of Tobacco Induced Diseases (Executive Committee Member, Secretary, Past President)
  • The Tobacco Control Research and Policy Unit, Hong Kong University (Advisor)
  • U.S. Surgeon General’s Report: Mechanisms of tobacco-induced pathologies – how cigarettes cause disease (Senior Reviewer).


University of Louisville

  • School of Interdisciplinary and Graduate Studies, Faculty  Council
  • School of Interdisciplinary and Graduate Studies, Dean’s Advisory Council
  • School of Interdisciplinary and Graduate Studies, Academic Affairs Committee
  • Provostial International Affairs Advisory Board


School of Dentistry

  • Post-graduate Academic Affairs Committee
  • Research Committee
  • Oral Biology Admissions and Curriculum Committee


Memberships

  • International Society for the Prevention of Tobacco Induced Diseases (Secretary; www.isptid.globalink.org)
  • International Association for Dental Research (Member; www.iadr.com)
  • Society for Anaerobic Microbiology (Member; www.clostridia.net/SAM/index.htm)
  • Society for Leukocyte Biology (Member; www.leukocytebiology.org)


Support Staff (Oral Biology Graduate Program)
Admissions: Dianne Foster (502) 852-1325
Post-admission: Jackie Williams (502) 852-5086

Publications
Books
“Molecular mechanisms of tobacco smoke-induced diseases”, Scott DA*, Wang XL, editors. Publisher: Nova Science Inc., 2006; ISBN 1-59454-514-6.

Chapters

  • Scott DA* and Bagaitkar J. Tobacco smoke and susceptibility to infectious bacterial diseases. In: “Cigarette Smoke Toxicity” David Bernhard, Editor. Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, 2010.
  • SCOTT DA*, WANG XL. “Mechanisms of Cigarette Smoking Induced Pathogenesis – An Overview” In: Molecular mechanisms of tobacco smoke-induced diseases. Scott DA and Wang XL, editors. Publisher: Nova Science Inc., 2006.
  • LIU K-Z, SOWA M, SCOTT DA*. “Infrared spectroscopy: A novel molecular tool for the quantification of tobacco smoke exposure and the early diagnosis of tobacco-induced diseases.” In: Molecular mechanisms of tobacco smoke-induced diseases. Scott DA and Wang XL, editors. Publisher: Nova Science Inc., 2006.
  • PALMER RM, WILSON RF, SCOTT DA*. “Periodontitis and tobacco smoking” In: Molecular mechanisms of tobacco smoke-induced diseases. Scott DA and Wang XL, editors. Publisher: Nova Science Inc., 2006.



Selected Recent Journal Articles

  • XIANG XM, LIU KZ, MAN A, GHIABI E, CHOLAKIS N AND SCOTT DA*. Periodontitis-specific molecular signatures in gingival crevicular fluid. Journal of Periodontal Research (in press, 2010).
  • BAGAITKAR J, DEMUTH DR, DAEP C, PIERCE DL, RENAUD DE, SCOTT DA*. Tobacco-regulated changes to P. gingivalis fimbrial proteins and capsule polysaccharides induce TLR2 hyposensitivity. PLOS One (in press, 2010).
  • GÜMÜS P, BUDUNELI N, CETINKALP S, HAWKINS SI, RENAUD DE, KINANE DF, SCOTT DA*. Salivary antioxidants in type 1 and type 2 diabetes patients with inflammatory periodontal disease. Journal of Periodontology 2009; 80: 1440-1406.
  • BAGAITKAR J, WILLIAMS LR, RENAUD DE, BEMAKANAKERE MR, SCOTT DA*, DEMUTH DR. Tobacco-induced alterations to Porphyromonas gingivalis gene activity and host-pathogen interactions. Environmental Microbiology 2009; 11:1242-1253.
  • LIU K-Z, XIANG XM, MAN A, SOWA MG, CHOLAKIS N, GHIABI E, SINGER DL , SCOTT DA*. In vivo determination of multiple indices of periodontal inflammation by near infrared optical spectroscopy. Journal of Periodontal Research 2009; 44: 117-124.
  • BAGAITKAR J, SCOTT DA*. Tobacco use and susceptibility to bacterial infection. Tobacco Induced diseases 2009; 4:12.
  • XU M, SCOTT JE, BISHOP HR, LIU K-Z, RENAUD DE, SOUSSI-GOUNNI A, SCOTT DA*. The influence of nicotine on granulocytic differentiation - inhibition of the oxidative burst and bacterial killing and increased matrix metalloproteinase-9 release. Cell Biology 2008;9:19.
  • REHANI K, MARTIN M, RENAUD DE, HAMZA H, WILLIAMS LR, SCOTT DA*. Cotinine-induced convergence of the cholinergic and PI3 kinase-dependent anti-inflammatory pathways in innate immune cells. Biochimica et Biophysica Acta: Molecular Cell Research 2008; 1783: 378-385.
  • FISHER S, KELLS L, PICARD J-P, GELSKEY SC, SINGER DL, LIX L, SCOTT DA*. Progression of periodontal disease in a maintenance population of smokers and validated non-smokers: a three-year longitudinal study. Journal of Periodontology 2008; 79: 461-468.


Patents

  • K.Z. Liu, DA Scott*, DL Singer and MG Sowa. A Means and Method for the Diagnosis of Periodontitis by Infrared Spectroscopy. U.S. Provisional Patent Application 60/780,060, (March 8) 2006.
  • D.A. Scott*, M. Martin. Therapeutic Cotinine Compositions. U.S. Patent Application 60/890,954 (February 21 2007).
  • D.A. Scott*, M. Martin. Therapeutic Cotinine Compositions. U.S. Patent Application PCT/US2008/054569 (February 21 2008).
  • D.A. Scott*, K.-Z. Liu. Molecular Signatures Of Diabetes In Saliva. U.S. Patent Application 61/139,263 (12/19/2008)

 

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