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Partha Mukhopadhyay, Ph.D.

Partha Mukhopadhyay, Ph.D.Partha Mukhopadhyay, Ph.D.
Assistant Professor
Department of Molecular, Cellular & Craniofacial Biology

Research Activities

Dr. Mukhopadhyay’s principal research focus involves investigation of the role and interaction of various peptide growth factors and transcriptional regulators, whose collective interplay can regulate neural tube and neural crest development, orofacial ontogenesis and palatogenesis. His specific research interests are to examine the role of the nuclear transcriptional regulators, coactivators and corepressors in craniofacial growth and anomalies, to analyze the role of growth factors like TGFßs and BMPs in orofacial development as well as characterization of the various transcription factors and their role in normal orofacial growth. Currently, he has been using DNA microarray technology to establish comprehensive “microRNA expression profiles” of developing murine orofacial tissue and of developing neural tube to identify important candidate microRNAs regulating palatogenesis and neural tube development, respectively. In addition, his current projects investigate: (1) BMP signaling (involving BMP receptor specific Smads such as Smad-1, Smad-5 and Smad-8/9) during orofacial development (2) the role of Id (inhibitor of differentiation) -1, Id-2, Id-3 and Id-4 helix-loop-helix transcription factors in orofacial ontogenesis (3) Epigenetic regulation of orofacial development (4) Epigenetics and Fetal Alcohol Syndrome and (5) Developmental neurotoxicity of prenatal environmental tobacco smoke exposure.

BMP.pngPeer-reviewed Publications

  • Mukhopadhyay P, Brock G, Pihur V, Webb C, Pisano MM, Greene RM. Developmental microRNA expression profiling of murine embryonic orofacial tissue. Birth Defects Res A: Clin Mol Teratol 88:511-534 (2010).
  • Mukhopadhyay P, Horn KH, Greene RM, Michele Pisano M. Prenatal exposure to environmental tobacco smoke alters gene expression in the developing murine hippocampus. Reprod Toxico 29:164-175 (2010).
  • Mukhopadhyay P, Rezzoug F, Webb CL, Pisano MM, Greene RM. Suppression of chondrogenesis by Id helix-loop-helix proteins in murine embryonic orofacial tissue. Differentiation 77: 462-472 (2009).

FunctionalGenetics.jpgGrants Funded

Role: Co-Investigator [Co-PIs: Eric Rouchka and Ted Kalbfleisch]
Title: “Extension of Informatics Infrastructure to Support Translational and Basic Research”
Funding Agency: Department of Energy
Direct Costs Funded: $1,194,300

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