Zi-Jian Lan, Ph.D.
Zi-Jian Lan, Ph.D.
Department of Molecular, Cellular and Craniofacial Biology
School of Dentistry
I. Research Activities
My research interest is to identify novel genetic factors in male and female reproduction using combined mouse genetic, molecular and cellular techniques. Currently we are investigating the function of FGF and PI3K signaling and zinc finger proteins in the gonad. Besides, the potential role of zinc finger proteins in modulating the action of steroid and/or orphan nuclear receptors in the gonad and mammary gland is also being investigated.
II. Grants Funded
Role: COBRE supported junior investigator
Title: Molecular studies of male and female reproduction
Funding Agency: National Institutes of Health/National Center for Research Resources
Grant Type: Center of Biological Research Excellence (COBRE)
Annul Direct Costs Funded: $157,500
- Lan ZJ, Xu X, Chung ACK, Cooney AJ. Extra-germ cell expression of mouse nuclear receptor subfamily 6, group A, member 1 (NR6A1). Biology of Reproduction 80:905–912 (2009).
- Adhikari D, Flohr G, Gorre N, Shen Y, Yang H, Lundin E, Lan ZJ, Gambello MJ, Liu K. Disruption of Tsc2 in oocytes leads to overactivation of the entire pool of primordial follicles. Molecular Human Reproduction 15:765-770 (2009).
- Adhikari D, Zheng W, Shen Y, Gorre N, Hämäläinen T, Cooney AJ, Huhtaniemi I, Lan ZJ, Liu K. Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles. Human Molecular Genetics 19(3):397-410 (2010).
- Zhou H, Liu L, Zhang H, Lei Z, Lan ZJ. Expression of zinc finger protein 105 in the testis and its role in male fertility. Molecular Reproduction & Development 77:511–520 (2010).
- Lei Z, Lin J, Li X, Li S, Zhou H, Araki Y, Lan ZJ. Postnatal male germ cell expression of Cre recombinase in Tex101-iCre transgenic mice. Genesis (in press) (2010).
IV. External activities