Division: Analytical Chemistry Specialty: Bioanalytical Chemistry & Bioinformatics Office: Shumaker Research Bld 349 Office Phone: 502-852-8878 Lab Phone: 502-852-3212 Email: xiang.zhang@louisville.edu Website: Zhang Group Web Page

1989 B.S.   Lanzhou University
1994 M.S.  Institute of Modern Physics, Chinese Academy of Sciences
2001 Ph.D. Purdue University

We are interested in multidisciplinary life sciences research. Our expectation is that the chemistry of biomolecules in living systems can define disease mechanisms. We would like to tell the biological story revealed by these molecules with advanced bioinformatics methodologies and modern analytical techniques. Our bioanalytical research exploits practical and efficient high-throughput technologies for the analyses of complex mixtures derived from living systems. The bioinformatics research in our group develops informatics system that enables mining of high-throughput data for molecular identification, quantification, molecular networks elucidation, and ‘systems level’ knowledge assembly.

A data pre-processing method for liquid chromatography mass spectrometry-based metabolomics.
Wei, X.; Shi, X.; Kim, S. H.; Zhang, L.; Patrick, J. S.; Binkley, J.; McClain, C.; Zhang, X.
Anal. Chem.  2012, 84, 7963-7971.

A method of calculating the second dimension hold-up time for comprehensive two-dimensional gas chromatography.
Koo, I.; Zhao, Y.; Zhang, J.; Kim, S.; Zhang, X.
J. Chromatogr. A  2012, 1260, 193-199.

A method of finding optimal weight factors for compound identification in gas chromatography–mass spectrometry.
Kim, S.; Koo, I.; Wei, X.; Zhang, X.
Bioinformatics  2012, 28(8), 1158-1163.

Metabolomic analysis of the effects of polychlorinated biphenyls in non-alcoholic fatty liver disease.
Shi, X.; Wahlang, B.; Wei, X.; Yin, X.; Falkner, K.; Prough, R.; Kim, S.; McClain, C.; Cave, M.; Zhang, X.
J. Proteome Res.  2012, 11, 3805–3815.

Compound identification using partial and semi-partial correlations for gas chromatography mass spectrometry data.
Kim, S.; Koo, I.; Jeong, J.; Wu, S.; Shi, X.; Zhang, X.
Anal. Chem.  2012, 84, 6477-6487.

A large scale test dataset to determine optimal retention index threshold based on three mass spectral similarity measures.
Zhang, J.; Koo, I.; Wang, B.; Gao, Q.; Zheng, C.; Zhang, X.
J. Chromatogr. A  2012, 1251, 188-193.

Fragmentation of oxime and silyl oxime ether odd-electron positive ions by the McLafferty rearrangement: new insights on structural factors that promote α,β-fragmentation.
Laulhe,S.; Bogdanov, B.; Johannes, L. M.; Gutierrez, O.; Harrison, J. G.; Tantillo, D. J.; Zhang, X.; Nantz, M. H.
J. Mass Spectrom.  2012, 47, 676-686.

Chronic alcohol exposure stimulates adipose tissue lipolysis in mice: Role of reverse triglyceride transport in the pathogenesis of alcoholic steatosis.
Zhong, W.; Zhao, Y.; Sun, X.; Wei, X.; Shi, X.; Sun, W.; Yin, X.; Sun, X.; Kim, S.; McClain, C. J.; Zhang, X.; Zhou, Z.
Am. J. Pathol.  2012, 180, 998-1007.

Model-based peak alignment of metabolomics profiling from comprehensive two-dimensional gas chromatography mass spectrometry.
Jeong, J.; Shi, X.; Zhang, X.; Kim, S.; Shen, C.
BMC Bioinformatics  2012, 13:27.