Xiang Zhang
Professor
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Division: Analytical Chemistry
Specialty: Bioanalytical Chemistry & Bioinformatics Office: Shumaker Research Bld 349 Phone: 502-852-8878 Email: xiang.zhang@louisville.edu Website: Zhang Group Web Page |
Education and Research Experience
1989 B.S. Lanzhou University
1994 M.S. Institute of Modern Physics, Chinese Academy of Sciences
2001 Ph.D. Purdue University
1994 M.S. Institute of Modern Physics, Chinese Academy of Sciences
2001 Ph.D. Purdue University
Research Interests
We are interested in multidisciplinary life sciences research. Our expectation is that the chemistry of biomolecules in living systems can define disease mechanisms. We would like to tell the biological story revealed by these molecules with advanced bioinformatics methodologies and modern analytical techniques. Our bioanalytical research exploits practical and efficient high-throughput technologies for the analyses of complex mixtures derived from living systems. The bioinformatics research in our group develops informatics system that enables mining of high-throughput data for molecular identification, quantification, molecular networks elucidation, and ‘systems level’ knowledge assembly.
Recent Publications
MetSign: A computational platform for high-resolution mass spectrometry-based metabolomics.
Wei, X.; Sun, W.; Shi, X.; Koo, I.; Wang, B.; Yin, X.; Tang, Y.; Bogdanov, B.; Kim, S. H.; Zhou, Z., McClain, C. J.; Zhang, X.
Anal. Chem. 2011, 83, 7668-7675.
iMatch, A retention index tool for analysis of gas chromatography mass spectrometry data.
Zhang, J.; Fang, A.; Wang, B.; Bogdanov, B.; Kim, S. H.; Zhou, Z.; McClain, C.; Zhang, X.
J. Chromatogr. A 2011, 1218, 6522-6530.
An empirical Bayes model using a competition score for metabolite identification in gas chromatography mass spectrometry.
Jeong, J.; Shi, X.; Zhang, X; Kim, S.; Shen, C.
BMC Bioinformatics 2011, 12:392.
Wavelet- and Fourier-Transforms-based spectrum similarity approaches to compound identification in gas chromatography/mass spectrometry.
Koo, I.; Zhang, X.; Kim, S.
Anal. Chem. 2011, 83, 5631-5638.
Smith-Waterman peak alignment for comprehensive two-dimensional gas chromatography mass spectrometry.
Kim, E.; Koo, I.; Fang, A.; Zhang, X.
BMC Bioinformatics 2011, 12:235.
A method of calculating the second dimension retention index in comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry.
Zhao, Y.; Zhang, J.; Wang, B.; Kim, S.; Fang, A.; Bogdanov, B.; Zhou, Z.; McClain, C.; Zhang, X.
J. Chromatogr. A 2011, 1218, 2577-2583.
A large, consistent plasma proteomics data set from prospectively collected breast cancer patient and healthy volunteer samples.
Riley, C. P.; Zhang, X.; Nakshatri, H.; Schneider, B.; Regnier, F. E.; Adamec, J.; Buck, C.
J. Transl. Med. 2011, 9:80.
Review on the book “Proteome Bioinformatics” (ISBN 978-1-60761-443-2)
Zhang, X.
Briefings in Bioinformatics 2011, 12, 80-81.
Mixture similarity peak alignment for comprehensive two-dimensional gas chromatography mass spectrometry based metabolomics
Kim, S.; Fang, A.; Wang, B.; Jeong, J.; Zhang, X.
Bioinformatics 2011, 27, 1660-1666.
Exacerbation of diabetes-induced testicular apoptosis by zinc deficiency is most likely associated with oxidative stress; p38 MAPK activation; and p53 activation in mice.
Zhao, Y.; Tan, Y.; Dai, J.; Li, B.; Guo, L.; Cui, J.; Wang, G.; Shi, X.; Zhang, X.; Mellen, N.; Li, W.; Cai, L.
Toxicol. Lett. 2011, 200, 100-106.
Wei, X.; Sun, W.; Shi, X.; Koo, I.; Wang, B.; Yin, X.; Tang, Y.; Bogdanov, B.; Kim, S. H.; Zhou, Z., McClain, C. J.; Zhang, X.
Anal. Chem. 2011, 83, 7668-7675.
iMatch, A retention index tool for analysis of gas chromatography mass spectrometry data.
Zhang, J.; Fang, A.; Wang, B.; Bogdanov, B.; Kim, S. H.; Zhou, Z.; McClain, C.; Zhang, X.
J. Chromatogr. A 2011, 1218, 6522-6530.
An empirical Bayes model using a competition score for metabolite identification in gas chromatography mass spectrometry.
Jeong, J.; Shi, X.; Zhang, X; Kim, S.; Shen, C.
BMC Bioinformatics 2011, 12:392.
Wavelet- and Fourier-Transforms-based spectrum similarity approaches to compound identification in gas chromatography/mass spectrometry.
Koo, I.; Zhang, X.; Kim, S.
Anal. Chem. 2011, 83, 5631-5638.
Smith-Waterman peak alignment for comprehensive two-dimensional gas chromatography mass spectrometry.
Kim, E.; Koo, I.; Fang, A.; Zhang, X.
BMC Bioinformatics 2011, 12:235.
A method of calculating the second dimension retention index in comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry.
Zhao, Y.; Zhang, J.; Wang, B.; Kim, S.; Fang, A.; Bogdanov, B.; Zhou, Z.; McClain, C.; Zhang, X.
J. Chromatogr. A 2011, 1218, 2577-2583.
A large, consistent plasma proteomics data set from prospectively collected breast cancer patient and healthy volunteer samples.
Riley, C. P.; Zhang, X.; Nakshatri, H.; Schneider, B.; Regnier, F. E.; Adamec, J.; Buck, C.
J. Transl. Med. 2011, 9:80.
Review on the book “Proteome Bioinformatics” (ISBN 978-1-60761-443-2)
Zhang, X.
Briefings in Bioinformatics 2011, 12, 80-81.
Mixture similarity peak alignment for comprehensive two-dimensional gas chromatography mass spectrometry based metabolomics
Kim, S.; Fang, A.; Wang, B.; Jeong, J.; Zhang, X.
Bioinformatics 2011, 27, 1660-1666.
Exacerbation of diabetes-induced testicular apoptosis by zinc deficiency is most likely associated with oxidative stress; p38 MAPK activation; and p53 activation in mice.
Zhao, Y.; Tan, Y.; Dai, J.; Li, B.; Guo, L.; Cui, J.; Wang, G.; Shi, X.; Zhang, X.; Mellen, N.; Li, W.; Cai, L.
Toxicol. Lett. 2011, 200, 100-106.
2011 A&S Distinguished Faculty Award
