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Teresa Whei-Mei Fan


Teresa W. Fan
Division: Biochemistry
Specialty: Systems Biochemistry
Phone: 502-852-6448
Email:  /
Website: CREAM  / Brown Cancer Center

Education and Research Experience

1977 B.S.   National Taiwan University
1979 M.S.  University of Hawaii
1983 Ph.D. University of California-Davis
1984-1986 Stanford University, Postdoctoral Research Associate

Research Interests

Fan’s research interest is in the application of stable isotope-resolved metabolomics (SIRM) in combination with transcriptomics for probing metabolic regulation and adaptation in model cells, model organisms and human in response to cancer development, therapeutics and environmental perturbations. Her present areas of research focus include deciphering distinct lung and breast cancer metabolism for developing early diagnostic markers and novel metabolic drug targets, and unraveling molecular mechanism underlying the toxic action of chemopreventive agents and metabolic inhibitors.

Publications (recent or significant)

Fan, T. W.-M., Lane, A. N., and Higashi, R. M. (2004). The Promise of Metabolomics in Cancer Molecular Therapeutics. Current Opnion in Molecular Therapeutics 6, 584-592.

Lane, A. N., Fan, T. W., and Higashi, R. M. (2008). Stable isotope-assisted metabolomics in cancer research. IUBMB Life 60, 124-129.

Fan, T., Bandura, L., Higashi, R., and Lane, A. (2005). Metabolomics-edited transcriptomics analysis of Se anticancer action in human lung cancer cells. Metabolomics Journal 1, 325-339

Fan, T. W.-M., and Lane, A. N. (2008). Structure-based profiling of Metabolites and Isotopomers by NMR. Progress in NMR Spectroscopy 52, 69-117.

Fan, T. W., Lane, A. N., Higashi, R. M., Farag, M. A., Gao, H., Bousamra, M., and Miller, D. M. (2009). Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM). Mol Cancer 8, 41.

Fan, T., Lane, A., Higashi, R., and Yan, J. (2011). Stable isotope resolved metabolomics of lung cancer in a SCID mouse model. Metabolomics 7, 257-269.

Fan, T. W., and Lane, A. N. (2011). NMR-based stable isotope resolved metabolomics in systems biochemistry. Journal of biomolecular NMR 49, 267-280.

Lane, A. N., Fan, T. W., Bousamra, M., Higashi, R. M., Yan, J., and Miller, D. M. (2011). Stable Isotope-Resolved Metabolomics (SIRM) in Cancer Research with Clinical Application to NonSmall Cell Lung Cancer. OMICS 15, 173-182.

Fan, T. W.-M., Yuan, P., Lane, A. N., Higashi, R. M., Wang, Y., Hamidi, A., Zhou, R., Guitart, X., Chen, G., Manji, H. K. M., and Kaddurah-Daouk, R. (2010). Stable Isotope-Resolved Metabolomic Analysis of Lithium Effects on Glial-Neuronal Metabolism and Interactions. Metabolomics 6, 165-179.

Lane, A. N., Fan, T. W., Xie, Z., Moseley, H. N., and Higashi, R. M. (2009). Isotopomer analysis of lipid biosynthesis by high resolution mass spectrometry and NMR. Analytica Chimica Acta 651, 201-208.

Moseley, H., Lane, A., Belshoff, A., Higashi, R., and Fan, T. (2011). A novel deconvolution method for modeling UDP-GlcNAc biosynthetic pathways based on 13C mass isotopologue profiles under non steady-state conditions. BMC Biology 9, 37.

Fan, T. W.-M., Tan, J. L., McKinney, M. M., and Lane, A. N. (in press, 2011). Stable Isotope Resolved Metabolomics Analysis of Ribonucleotide and RNA Metabolism in Human Lung Cancer Cells. Metabolomics in press, 2011.

Fan, T. W.-M., and Lane, A. N., eds. (2012). Multi-Dimensional and Multi-Nuclear NMR Assignment Strategies for Metabolomics,  (Cambridge: Cambridge University Press).

Yuneva, M. O., Fan, T. W.-M., Higashi, R. M., Allen, T. A., Balakrishnan, A., Goga, A., Ferraris, D. V., Tsukamoto, T., Wang, C., Seo, Y., et al. (in press, 2012). The Initiating Oncogenic Lesion Determines Metabolic Properties of Tumors and Cellular Sensitivity to Inhibition of Glutaminase. Cell Metabolism.

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