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Eugene G. Mueller

Charles L. Bloch Professor

Eugene G. Mueller
Division: Biochemistry
Specialty: Mechanistic Enzymology
Phone: 502-852-5811
Website: Mueller Research Group

Education and Research Experience

1987 B.S.   University of Illinois–Urbana
1992 Ph.D. Harvard University

Research Interests

tRNA Modification
Sulfur Transfer
Bioorganic Mechanism

Publications (recent or significant)

Crystal Structure of Pseudouridine Synthase RluA: Indirect Sequence Readout through Protein-Induced RNA Structure
C. Hoang, J. Chen, C. A. Vizthum, J. M. Kandel, C. S. Hamilton, E. G. Mueller, and A. R. Ferré-d'Amaré
Mol. Cell 2006, 24, 535-545

Mechanistic Investigations of the Pseudouridine Synthase RluA Using RNA Containing 5-Fluorouridine
C. S. Hamilton, T. M. Greco, C. A. Vizthum, J. M. Ginter, M. V. Johnston, and E. G. Mueller
Biochemistry 2006, 39, 12019-12038

Direct evidence for enzyme persulfide and disulfide intermediates during 4-thiouridine biosynthesis
C. M. Wright, G. D. Christman, A. M. Snellinger, M. V. Johnston, and E. G. Mueller
Chem. Comm. 2006, 3104-3106

Trafficking in persulfides: delivering sulfur in biosynthetic pathways
E. G. Mueller
Nature Chem. Biol. 2006, 4, 185-194
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