Welcome to the UofL Department of Chemistry
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Chemistry at Louisville continues to build on its strong traditions. The members of our faculty are accomplished teacher-scholars who maintain exciting research programs in the myriad arenas that comprise the modern chemical sciences. Our department offers Ph.D. and M.S. degrees plus a variety of degree options for undergraduate students (read additional remarks from the chair: Message from the Chair). |
Recent Departmental Publications:
N-(2-formyl-1-methylimidazol-4-yl)-2,2-dimethylpropanamide: a versatile reagent for preparing imidazole-amine ligands with variable second-coordination spheres
Cheruzel LE, Cui J, Mashuta MS, Grapperhaus CA, Buchanan RM.
Tetrahedron Lett 2011 52, 4771-4774.
Overview of Metabolomics in Handbook of Metabolomics
Fan TW-M, Higashi RM, Lane AN.
Humana Press 2011 Fan, Lane & Higashi editors.
Stable Isotope Resolved Metabolomics of Lung Cancer in a SCID Mouse Model
Fan TW-M, Lane AN, Higashi RM, Yan J.
Metabolomics 2011, 7, 257-269 DOI: 10.1007/s11306-010-0249-0
Scaled up version of CBH1 from a cellulose Mixture by Ion Exchange Chromatography.
Ye Z, Lane AN, Berson E.
Biotech. Progress 2011 in press.
Stable Isotope Resolved Metabolomics Analysis of Ribonucleotide and RNA Metabolism in Human Lung Cancer Cells.
Fan TW-M, Tan J, McKinney MM, Lane AN.
Metabolomics 2011 In press.
Synthesis Of Fluorohydrins Through Electrophilic Fluorination Of Allyl Silanes
Xu B, Wang W, Hammond GB.
Synthesis 2011 (doi: 10.1055/s-0030-1260074).
Library-Friendly Synthesis Of Fluorinated Ketones Through Functionalized Hydration Of Alkynes And Investigation Of The Reaction Mechanism
Xu B, Wang W, Hammond GB.
J. Fluorine Chem. 2011 (doi:10.1016/j.jfluchem.2011.05.006).
Construction of Cyclic Enones via Gold-Catalyzed Oxygen Transfer Reactions
Liu L, Xu B, Hammond GB.
Beilstein J. Org. Chem. 2011, 7, 606-614.
Role of calcium in the conformational dynamics of factor XIII activation examined by hydrogen/deuterium exchange coupled with MALDI-TOF MS.
Woofter RT, Maurer MC.
Arch Biochem Biophys. 2011 May 26. [Epub ahead of print]
A novel method for deconvoluting metabolic subunits from mass isotopologues in stable isotope resolved metabolomic experiments under non steady-state conditions: application to the biosynthesis of UDP-GlcNAc
Hunter N.B. Moseley, Andrew N. Lane, Alex C. Belshoff, Richard M. Higashi, and Teresa W-M. Fan
BMC Biology 2011 in press
Metal-Stabilized Thiyl Radicals as Scaffolds for Reversible Alkene Addition via C-S Bond Formation/Cleavage.
Ouch K, Mashuta MS, Grapperhaus CA.
Inorg Chem. 2011 May 25. [Epub ahead of print]
Cytotoxic and Anti-infective Phenolic Compounds Isolated from Mikania decora and Cremastosperma microcarpum.
Aponte JC, Jin Z, Vaisberg AJ, Castillo D, Málaga E, Lewis WH, Sauvain M, Gilman RH, Hammond GB.
Planta Med. 2011 Apr 6. [Epub ahead of print]
A method of calculating the second dimension retention index in comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry.
Zhao, Y.; Zhang, J.; Wang, B.; Kim, S.; Fang, A.; Bogdanov, B.; Zhou, Z.; McClain, C.; Zhang, X.
J. Chromatogr. A 2011, 1218, 2577-2583.
Mixture similarity peak alignment for comprehensive two-dimensional gas chromatography mass spectrometry based metabolomics
Kim, S.; Fang, A.; Wang, B.; Jeong, J.; Zhang, X.
Bioinformatics 2011, 27, 1660-1666.
A large, consistent plasma proteomics data set from prospectively collected breast cancer patient and healthy volunteer samples.
Riley, C. P.; Zhang, X.; Nakshatri, H.; Schneider, B.; Regnier, F. E.; Adamec, J.; Buck, C.
J. Transl. Med. 2011, 9:80.
Exacerbation of diabetes-induced testicular apoptosis by zinc deficiency is most likely associated with oxidative stress; p38 MAPK activation; and p53 activation in mice.
Zhao, Y.; Tan, Y.; Dai, J.; Li, B.; Guo, L.; Cui, J.; Wang, G.; Shi, X.; Zhang, X.; Mellen, N.; Li, W.; Cai, L.
Toxicol. Lett. 2011, 200, 100-106.
Switching cation-binding loops paves the way for redesigning allosteric activation.
Maurer MC.
Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5145-6. Epub 2011 Mar 17. No abstract available.
Click assembly of magnetic nanovectors for gene delivery.
Biswas S, Gordon LE, Clark GJ, Nantz MH.
Biomaterials. 2011 Apr;32(10):2683-8. Epub 2011 Jan 20.
Human meibum lipid conformation and thermodynamic changes with meibomian-gland dysfunction.
Borchman D, Foulks GN, Yappert MC, Bell J, Wells E, Neravetla S, Greenstone V.
Invest Ophthalmol Vis Sci. 2011 Jun 1;52(6):3805-17. Print 2011.
Hydrogen reactivity of palladium nanoparticles coated with mixed monolayers of alkyl thiols and alkyl amines for sensing and catalysis applications.
Moreno M, Ibañez FJ, Jasinski JB, Zamborini FP.
J Am Chem Soc. 2011 Mar 30;133(12):4389-97. Epub 2011 Feb 25.
Electrochemical Fabrication of Metal/Organic/Metal Junctions for Molecular Electronics and Sensing Applications.
Dasari R, Ibañez FJ, Zamborini FP.
Langmuir. 2011 Jun 7;27(11):7285-7293. Epub 2010 Nov 12.
Electronic structure of cofactor-substrate reactant complex involved in the methyl transfer reaction catalyzed by cobalamin-dependent methionine synthase.
Kumar N, Jaworska M, Lodowski P, Kumar M, Kozlowski PM.
J Phys Chem B. 2011 May 26;115(20):6722-31. Epub 2011 May 3.
Electronically excited states of vitamin B12: benchmark calculations including time-dependent density functional theory and correlated ab initio methods.
Kornobis K, Kumar N, Wong BM, Lodowski P, Jaworska M, Andruniów T, Ruud K, Kozlowski PM.
J Phys Chem A. 2011 Feb 24;115(7):1280-92. Epub 2011 Jan 31.
Electronically excited states of vitamin B12 and methylcobalamin: theoretical analysis of absorption, CD, and MCD data.
Solheim H, Kornobis K, Ruud K, Kozlowski PM.
J Phys Chem B. 2011 Feb 3;115(4):737-48. Epub 2010 Dec 21.
Synthesis of α-CN and α-CF(3) N-Heterocycles through Tandem Nucleophilic Additions.
Han J, Xu B, Hammond GB.
Org Lett. 2011 Jun 2. [Epub ahead of print]
NMR-based stable isotope resolved metabolomics in systems biochemistry.
Fan TW, Lane AN.
J Biomol NMR. 2011 Apr;49(3-4):267-80. Epub 2011 Feb 26.
Lipid-mediated delivery of RNA is more efficient than delivery of DNA in non-dividing cells.
Zou S, Scarfo K, Nantz MH, Hecker JG.
Int J Pharm. 2010 Apr 15;389(1-2):232-43. Epub 2010 Jan 18.
DISCO: distance and spectrum correlation optimization alignment for two-dimensional gas chromatography time-of-flight mass spectrometry-based metabolomics.
Wang B, Fang A, Heim J, Bogdanov B, Pugh S, Libardoni M, Zhang X.
Anal Chem. 2010 Jun 15;82(12):5069-81.
Dual inhibition of sodium-mediated proton and calcium efflux triggers non-apoptotic cell death in malignant gliomas.
Harley W, Floyd C, Dunn T, Zhang XD, Chen TY, Hegde M, Palandoken H, Nantz MH, Leon L, Carraway KL 3rd, Lyeth B, Gorin FA.
Brain Res. 2010 Dec 2;1363:159-69. Epub 2010 Oct 13.
Stable isotope-resolved metabolomics (SIRM) in cancer research with clinical application to nonsmall cell lung cancer.
Lane AN, Fan TW, Bousamra M 2nd, Higashi RM, Yan J, Miller DM.
OMICS. 2011 Mar;15(3):173-82. Epub 2011 Feb 17.
Controlled sulfur oxygenation of the ruthenium dithiolate (4,7-bis-(2'-methyl-2'-mercaptopropyl)-1-thia-4,7-diazacyclononane)RuPPh(3) under limiting O(2) conditions yields thiolato/sulfinato, sulfenato/sulfinato, and bis-sulfinato derivatives.
Masitas CA, Kumar M, Mashuta MS, Kozlowski PM, Grapperhaus CA.
Inorg Chem. 2010 Dec 6;49(23):10875-81. Epub 2010 Oct 26.
The Handling of the Mechanistic Probe 5-Fluorouridine by the Pseudouridine Synthase TruA and Its Consistency with the Handling of the Same Probe by the Pseudouridine Synthases TruB and RluA.
McDonald MK, Miracco EJ, Chen J, Xie Y, Mueller EG.
Biochemistry. 2010 Dec 29. [Epub ahead of print]
Reductive cleavage mechanism of Co-C bond in cobalamin-dependent methionine synthase.
Alfonso-Prieto M, Biarnés X, Kumar M, Rovira C, Kozlowski PM.
J Phys Chem B. 2010 Oct 14;114(40):12965-71.
Molecular fluorescence, phosphorescence, and chemiluminescence spectrometry.
Powe AM, Das S, Lowry M, El-Zahab B, Fakayode SO, Geng ML, Baker GA, Wang L, McCarroll ME, Patonay G, Li M, Aljarrah M, Neal S, Warner IM.
Anal Chem. 2010 Jun 15;82(12):4865-94. No abstract available.
Edelfosine-induced metabolic changes in cancer cells that precede the overproduction of reactive oxygen species and apoptosis.
Selivanov VA, Vizán P, Mollinedo F, Fan TW, Lee PW, Cascante M.
BMC Syst Biol. 2010 Oct 6;4:135.
Stable isotope-resolved metabolomic analysis of lithium effects on glial-neuronal metabolism and interactions.
Fan TW, Yuan P, Lane AN, Higashi RM, Wang Y, Hamidi AB, Zhou R, Guitart X, Chen G, Manji HK, Kaddurah-Daouk R.
Metabolomics. 2010 Jun 1;6(2):165-179.
Synthesis, structure, and solution properties of [(mim-TASN)FeCl2]+ and its μ-oxo derivative.
Cui J, Mashuta MS, Buchanan RM, Grapperhaus CA. Inorg Chem. 2010 Nov 15;49(22):10427-35. Epub 2010 Oct 14.
Potential-controlled electrochemical seed-mediated growth of gold nanorods directly on electrode surfaces.
Abdelmoti LG, Zamborini FP.
Langmuir. 2010 Aug 17;26(16):13511-21.
Purification of gold nanoplates grown directly on surfaces for enhanced localized surface plasmon resonance biosensing.
Beeram SR, Zamborini FP.
ACS Nano. 2010 Jul 27;4(7):3633-46.
Electrochemical size discrimination of gold nanoparticles attached to glass/indium-tin-oxide electrodes by oxidation in bromide-containing electrolyte.
Ivanova OS, Zamborini FP.
Anal Chem. 2010 Jul 1;82(13):5844-50.
Confirmation of changes in human meibum lipid infrared spectra with age using principal component analysis.
Borchman D, Foulks GN, Yappert MC.
Curr Eye Res. 2010 Sep;35(9):778-86.
Changes in human meibum lipid with meibomian gland dysfunction using principal component analysis.
Borchman D, Yappert MC, Foulks GN.
Exp Eye Res. 2010 Aug;91(2):246-56. Epub 2010 May 28.
Synthetic Evolutions in the Nucleophilic Addition to Alkynes
B. Xu, W. Wang, L. Liu, J. Han, Z. Jin and G. B. Hammond
J. Organomet. Chem. 2010 (in press 10.1016/j.jorganchem.2010.09.025).
Tandem Michael Addition/Aldol Reaction of Allenic Ketones with Alkyl Vinyl Ketones: Versatile Synthesis of 2-Alkynyl-1,5-Diketones, 4-Alkynyl-3-Hydroxycyclohexones and 4-Alkynylcyclohexenones
D. Malhotra, L. Liu, G. B. Hammond
Eur. J. Org. Chem. 2010 (in press 10.1002/ejoc.201001161).
The [4+2], not [2+2] Mechanism Occurs in the Gold-Catalyzed Intramolecular Oxygen Transfer Reaction of 2-Alkynyl-1,5-Diketones
L. Liu, D. Malhotra, R. S. Paton, K. N. Houk, and G. B. Hammond
Angew. Chem. Int. Ed. 2010 49, 9132 – 9135.
Gold-Catalyzed Cascade Annulations of 2-(Ynol)Aryl Aldehydes: Facile Synthesis of Benzochromanes and Benzobicyclo[n.3.1]acetals
L. Liu and G. B. Hammond
Org. Lett. 2010 12, 4640-4643.
Fluorine-enabled cationic gold catalysis: Functionalized hydration of alkynes
W. Wang, B. Xu, G. B. Hammond
Angew. Chem. Int. Ed. 2010 49, 7247-7252.
Transformative Syntheses of Fluorinated Heterocyclics Using a Difluorohomopropargylic Template
S. Arimitsu and G. B. Hammond
Chimica Oggi/Chemistry Today 2010 28, 20-22.
From Vinylogation to Alkynylogation: Extending the Reactivity of Enolates
B. Xu and G. B. Hammond
Synlett Account 2010 1442-1454.
Synthesis of fluorinated δ-lactams via cycloisomerization of gem-difluoropropargyl amides
S. Arimitsu and G. B. Hammond
Beilstein J. Org. Chem. 2010 6, No. 48 (doi:10.3762/bjoc.6.48).
In Vitro and In Vivo Anti-Leishmania Activity of Polysubstituted Synthetic Chalcones
J. C. Aponte, D. Castillo, Y. Estevez, G. Gonzalez, J. Arevalo, G. B. Hammond
M. Sauvain Bioorg. Med. Chem. Lett. 2010, 20, 100-103.
Green Synthesis of Vicinal Dithioethers and Alkenyl Thioethers from the Reaction of Alkynes and Thiols in Water
Z. Jin, B. Xu, G. B. Hammond
Cheruzel LE, Cui J, Mashuta MS, Grapperhaus CA, Buchanan RM.
Tetrahedron Lett 2011 52, 4771-4774.
Overview of Metabolomics in Handbook of Metabolomics
Fan TW-M, Higashi RM, Lane AN.
Humana Press 2011 Fan, Lane & Higashi editors.
Stable Isotope Resolved Metabolomics of Lung Cancer in a SCID Mouse Model
Fan TW-M, Lane AN, Higashi RM, Yan J.
Metabolomics 2011, 7, 257-269 DOI: 10.1007/s11306-010-0249-0
Scaled up version of CBH1 from a cellulose Mixture by Ion Exchange Chromatography.
Ye Z, Lane AN, Berson E.
Biotech. Progress 2011 in press.
Stable Isotope Resolved Metabolomics Analysis of Ribonucleotide and RNA Metabolism in Human Lung Cancer Cells.
Fan TW-M, Tan J, McKinney MM, Lane AN.
Metabolomics 2011 In press.
Synthesis Of Fluorohydrins Through Electrophilic Fluorination Of Allyl Silanes
Xu B, Wang W, Hammond GB.
Synthesis 2011 (doi: 10.1055/s-0030-1260074).
Library-Friendly Synthesis Of Fluorinated Ketones Through Functionalized Hydration Of Alkynes And Investigation Of The Reaction Mechanism
Xu B, Wang W, Hammond GB.
J. Fluorine Chem. 2011 (doi:10.1016/j.jfluchem.2011.05.006).
Construction of Cyclic Enones via Gold-Catalyzed Oxygen Transfer Reactions
Liu L, Xu B, Hammond GB.
Beilstein J. Org. Chem. 2011, 7, 606-614.
Role of calcium in the conformational dynamics of factor XIII activation examined by hydrogen/deuterium exchange coupled with MALDI-TOF MS.
Woofter RT, Maurer MC.
Arch Biochem Biophys. 2011 May 26. [Epub ahead of print]
A novel method for deconvoluting metabolic subunits from mass isotopologues in stable isotope resolved metabolomic experiments under non steady-state conditions: application to the biosynthesis of UDP-GlcNAc
Hunter N.B. Moseley, Andrew N. Lane, Alex C. Belshoff, Richard M. Higashi, and Teresa W-M. Fan
BMC Biology 2011 in press
Metal-Stabilized Thiyl Radicals as Scaffolds for Reversible Alkene Addition via C-S Bond Formation/Cleavage.
Ouch K, Mashuta MS, Grapperhaus CA.
Inorg Chem. 2011 May 25. [Epub ahead of print]
Cytotoxic and Anti-infective Phenolic Compounds Isolated from Mikania decora and Cremastosperma microcarpum.
Aponte JC, Jin Z, Vaisberg AJ, Castillo D, Málaga E, Lewis WH, Sauvain M, Gilman RH, Hammond GB.
Planta Med. 2011 Apr 6. [Epub ahead of print]
A method of calculating the second dimension retention index in comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry.
Zhao, Y.; Zhang, J.; Wang, B.; Kim, S.; Fang, A.; Bogdanov, B.; Zhou, Z.; McClain, C.; Zhang, X.
J. Chromatogr. A 2011, 1218, 2577-2583.
Mixture similarity peak alignment for comprehensive two-dimensional gas chromatography mass spectrometry based metabolomics
Kim, S.; Fang, A.; Wang, B.; Jeong, J.; Zhang, X.
Bioinformatics 2011, 27, 1660-1666.
A large, consistent plasma proteomics data set from prospectively collected breast cancer patient and healthy volunteer samples.
Riley, C. P.; Zhang, X.; Nakshatri, H.; Schneider, B.; Regnier, F. E.; Adamec, J.; Buck, C.
J. Transl. Med. 2011, 9:80.
Exacerbation of diabetes-induced testicular apoptosis by zinc deficiency is most likely associated with oxidative stress; p38 MAPK activation; and p53 activation in mice.
Zhao, Y.; Tan, Y.; Dai, J.; Li, B.; Guo, L.; Cui, J.; Wang, G.; Shi, X.; Zhang, X.; Mellen, N.; Li, W.; Cai, L.
Toxicol. Lett. 2011, 200, 100-106.
Switching cation-binding loops paves the way for redesigning allosteric activation.
Maurer MC.
Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5145-6. Epub 2011 Mar 17. No abstract available.
Click assembly of magnetic nanovectors for gene delivery.
Biswas S, Gordon LE, Clark GJ, Nantz MH.
Biomaterials. 2011 Apr;32(10):2683-8. Epub 2011 Jan 20.
Human meibum lipid conformation and thermodynamic changes with meibomian-gland dysfunction.
Borchman D, Foulks GN, Yappert MC, Bell J, Wells E, Neravetla S, Greenstone V.
Invest Ophthalmol Vis Sci. 2011 Jun 1;52(6):3805-17. Print 2011.
Hydrogen reactivity of palladium nanoparticles coated with mixed monolayers of alkyl thiols and alkyl amines for sensing and catalysis applications.
Moreno M, Ibañez FJ, Jasinski JB, Zamborini FP.
J Am Chem Soc. 2011 Mar 30;133(12):4389-97. Epub 2011 Feb 25.
Electrochemical Fabrication of Metal/Organic/Metal Junctions for Molecular Electronics and Sensing Applications.
Dasari R, Ibañez FJ, Zamborini FP.
Langmuir. 2011 Jun 7;27(11):7285-7293. Epub 2010 Nov 12.
Electronic structure of cofactor-substrate reactant complex involved in the methyl transfer reaction catalyzed by cobalamin-dependent methionine synthase.
Kumar N, Jaworska M, Lodowski P, Kumar M, Kozlowski PM.
J Phys Chem B. 2011 May 26;115(20):6722-31. Epub 2011 May 3.
Electronically excited states of vitamin B12: benchmark calculations including time-dependent density functional theory and correlated ab initio methods.
Kornobis K, Kumar N, Wong BM, Lodowski P, Jaworska M, Andruniów T, Ruud K, Kozlowski PM.
J Phys Chem A. 2011 Feb 24;115(7):1280-92. Epub 2011 Jan 31.
Electronically excited states of vitamin B12 and methylcobalamin: theoretical analysis of absorption, CD, and MCD data.
Solheim H, Kornobis K, Ruud K, Kozlowski PM.
J Phys Chem B. 2011 Feb 3;115(4):737-48. Epub 2010 Dec 21.
Synthesis of α-CN and α-CF(3) N-Heterocycles through Tandem Nucleophilic Additions.
Han J, Xu B, Hammond GB.
Org Lett. 2011 Jun 2. [Epub ahead of print]
NMR-based stable isotope resolved metabolomics in systems biochemistry.
Fan TW, Lane AN.
J Biomol NMR. 2011 Apr;49(3-4):267-80. Epub 2011 Feb 26.
Lipid-mediated delivery of RNA is more efficient than delivery of DNA in non-dividing cells.
Zou S, Scarfo K, Nantz MH, Hecker JG.
Int J Pharm. 2010 Apr 15;389(1-2):232-43. Epub 2010 Jan 18.
DISCO: distance and spectrum correlation optimization alignment for two-dimensional gas chromatography time-of-flight mass spectrometry-based metabolomics.
Wang B, Fang A, Heim J, Bogdanov B, Pugh S, Libardoni M, Zhang X.
Anal Chem. 2010 Jun 15;82(12):5069-81.
Dual inhibition of sodium-mediated proton and calcium efflux triggers non-apoptotic cell death in malignant gliomas.
Harley W, Floyd C, Dunn T, Zhang XD, Chen TY, Hegde M, Palandoken H, Nantz MH, Leon L, Carraway KL 3rd, Lyeth B, Gorin FA.
Brain Res. 2010 Dec 2;1363:159-69. Epub 2010 Oct 13.
Stable isotope-resolved metabolomics (SIRM) in cancer research with clinical application to nonsmall cell lung cancer.
Lane AN, Fan TW, Bousamra M 2nd, Higashi RM, Yan J, Miller DM.
OMICS. 2011 Mar;15(3):173-82. Epub 2011 Feb 17.
Controlled sulfur oxygenation of the ruthenium dithiolate (4,7-bis-(2'-methyl-2'-mercaptopropyl)-1-thia-4,7-diazacyclononane)RuPPh(3) under limiting O(2) conditions yields thiolato/sulfinato, sulfenato/sulfinato, and bis-sulfinato derivatives.
Masitas CA, Kumar M, Mashuta MS, Kozlowski PM, Grapperhaus CA.
Inorg Chem. 2010 Dec 6;49(23):10875-81. Epub 2010 Oct 26.
The Handling of the Mechanistic Probe 5-Fluorouridine by the Pseudouridine Synthase TruA and Its Consistency with the Handling of the Same Probe by the Pseudouridine Synthases TruB and RluA.
McDonald MK, Miracco EJ, Chen J, Xie Y, Mueller EG.
Biochemistry. 2010 Dec 29. [Epub ahead of print]
Reductive cleavage mechanism of Co-C bond in cobalamin-dependent methionine synthase.
Alfonso-Prieto M, Biarnés X, Kumar M, Rovira C, Kozlowski PM.
J Phys Chem B. 2010 Oct 14;114(40):12965-71.
Molecular fluorescence, phosphorescence, and chemiluminescence spectrometry.
Powe AM, Das S, Lowry M, El-Zahab B, Fakayode SO, Geng ML, Baker GA, Wang L, McCarroll ME, Patonay G, Li M, Aljarrah M, Neal S, Warner IM.
Anal Chem. 2010 Jun 15;82(12):4865-94. No abstract available.
Edelfosine-induced metabolic changes in cancer cells that precede the overproduction of reactive oxygen species and apoptosis.
Selivanov VA, Vizán P, Mollinedo F, Fan TW, Lee PW, Cascante M.
BMC Syst Biol. 2010 Oct 6;4:135.
Stable isotope-resolved metabolomic analysis of lithium effects on glial-neuronal metabolism and interactions.
Fan TW, Yuan P, Lane AN, Higashi RM, Wang Y, Hamidi AB, Zhou R, Guitart X, Chen G, Manji HK, Kaddurah-Daouk R.
Metabolomics. 2010 Jun 1;6(2):165-179.
Synthesis, structure, and solution properties of [(mim-TASN)FeCl2]+ and its μ-oxo derivative.
Cui J, Mashuta MS, Buchanan RM, Grapperhaus CA. Inorg Chem. 2010 Nov 15;49(22):10427-35. Epub 2010 Oct 14.
Potential-controlled electrochemical seed-mediated growth of gold nanorods directly on electrode surfaces.
Abdelmoti LG, Zamborini FP.
Langmuir. 2010 Aug 17;26(16):13511-21.
Purification of gold nanoplates grown directly on surfaces for enhanced localized surface plasmon resonance biosensing.
Beeram SR, Zamborini FP.
ACS Nano. 2010 Jul 27;4(7):3633-46.
Electrochemical size discrimination of gold nanoparticles attached to glass/indium-tin-oxide electrodes by oxidation in bromide-containing electrolyte.
Ivanova OS, Zamborini FP.
Anal Chem. 2010 Jul 1;82(13):5844-50.
Confirmation of changes in human meibum lipid infrared spectra with age using principal component analysis.
Borchman D, Foulks GN, Yappert MC.
Curr Eye Res. 2010 Sep;35(9):778-86.
Changes in human meibum lipid with meibomian gland dysfunction using principal component analysis.
Borchman D, Yappert MC, Foulks GN.
Exp Eye Res. 2010 Aug;91(2):246-56. Epub 2010 May 28.
Synthetic Evolutions in the Nucleophilic Addition to Alkynes
B. Xu, W. Wang, L. Liu, J. Han, Z. Jin and G. B. Hammond
J. Organomet. Chem. 2010 (in press 10.1016/j.jorganchem.2010.09.025).
Tandem Michael Addition/Aldol Reaction of Allenic Ketones with Alkyl Vinyl Ketones: Versatile Synthesis of 2-Alkynyl-1,5-Diketones, 4-Alkynyl-3-Hydroxycyclohexones and 4-Alkynylcyclohexenones
D. Malhotra, L. Liu, G. B. Hammond
Eur. J. Org. Chem. 2010 (in press 10.1002/ejoc.201001161).
The [4+2], not [2+2] Mechanism Occurs in the Gold-Catalyzed Intramolecular Oxygen Transfer Reaction of 2-Alkynyl-1,5-Diketones
L. Liu, D. Malhotra, R. S. Paton, K. N. Houk, and G. B. Hammond
Angew. Chem. Int. Ed. 2010 49, 9132 – 9135.
Gold-Catalyzed Cascade Annulations of 2-(Ynol)Aryl Aldehydes: Facile Synthesis of Benzochromanes and Benzobicyclo[n.3.1]acetals
L. Liu and G. B. Hammond
Org. Lett. 2010 12, 4640-4643.
Fluorine-enabled cationic gold catalysis: Functionalized hydration of alkynes
W. Wang, B. Xu, G. B. Hammond
Angew. Chem. Int. Ed. 2010 49, 7247-7252.
Transformative Syntheses of Fluorinated Heterocyclics Using a Difluorohomopropargylic Template
S. Arimitsu and G. B. Hammond
Chimica Oggi/Chemistry Today 2010 28, 20-22.
From Vinylogation to Alkynylogation: Extending the Reactivity of Enolates
B. Xu and G. B. Hammond
Synlett Account 2010 1442-1454.
Synthesis of fluorinated δ-lactams via cycloisomerization of gem-difluoropropargyl amides
S. Arimitsu and G. B. Hammond
Beilstein J. Org. Chem. 2010 6, No. 48 (doi:10.3762/bjoc.6.48).
In Vitro and In Vivo Anti-Leishmania Activity of Polysubstituted Synthetic Chalcones
J. C. Aponte, D. Castillo, Y. Estevez, G. Gonzalez, J. Arevalo, G. B. Hammond
M. Sauvain Bioorg. Med. Chem. Lett. 2010, 20, 100-103.
Green Synthesis of Vicinal Dithioethers and Alkenyl Thioethers from the Reaction of Alkynes and Thiols in Water
Z. Jin, B. Xu, G. B. Hammond
Eur. J. Org. Chem. 2010 168-173.
Automated Protein Resonance Assignments of Magic Angle Spinning
Solid-State NMR Spectra of β1 Immunoglobulin Binding Domain of Protein G
(GB1).
Hunter N.B. Moseley, Lindsay J. Sperling, and Chad M. Rienstra.
J Biomol NMR accepted.
Counterion condensation and shape within poisson-boltzmann theory.
Lamm G, Pack GR.
Biopolymers. 2010 Mar 8 (Epub ahead of print).
Enabling individualized therapy through nanotechnology.
Sakamoto JH, van de Ven AL, Godin B, Blanco E, Serda RE, Grattoni A, Ziemys A, Bouamrani A, Hu T, Ranganathan SI, De Rosa E, Martinez JO, Smid CA, Buchanan RM, Lee SY, Srinivasan S, Landry M, Meyn A, Tasciotti E, Liu X, Decuzzi P, Ferrari M.
Pharmacol Res. 2010 Jan 5 (Epub ahead of print).
Asymmetric Oxygenation of a Ruthenium Dithiolate Mimics the Mixed Sulfenato/Sulfinato Donor Sets of Nitrile Hydratase and Thiocyanate Hydrolase.
Masitas CA, Mashuta MS, Grapperhaus CA.
Inorg Chem. 2010 May 20. (Epub ahead of print).
Resolution and characterization of the structural polymorphism of a single quadruplex-forming sequence.
Dailey MM, Miller MC, Bates PJ, Lane AN, Trent JO.
Nucleic Acids Res. 2010 Mar 25 (Epub ahead of print).
The Benefit of Hydrophobic Domain Asymmetry on the Efficacy of Transfection as Measured by in Vivo Imaging.
Nantz MH, Dicus CW, Hilliard B, Yellayi S, Zou S, Hecker JG.
Mol Pharm. 2010 Apr 9 (Epub ahead of print).
Lipids and the ocular lens.
Borchman D, Yappert MC.
J Lipid Res. 2010 Apr 20 (Epub ahead of print).
Self-calibrating microfabricated iridium oxide pH electrode array for remote monitoring.
Carroll S, Baldwin RP.
Anal Chem. 2010 Feb 1;82(3):878-85.
Trypanoside, anti-tuberculosis, leishmanicidal, and cytotoxic activities of tetrahydrobenzothienopyrimidines.
Aponte JC, Vaisberg AJ, Castillo D, Gonzalez G, Estevez Y, Arevalo J, Quiliano M, Zimic M, Verástegui M, Málaga E, Gilman RH, Bustamante JM, Tarleton RL, Wang Y, Franzblau SG, Pauli GF, Sauvain M, Hammond GB.
Bioorg Med Chem. 2010 Apr 15;18(8):2880-6.
Highly efficient Cu(I)-catalyzed synthesis of N-heterocycles through a cyclization-triggered addition of alkynes.
Han J, Xu B, Hammond GB.
J Am Chem Soc. 2010 Jan 27;132(3):916-7
Cytotoxic and anti-infective sesquiterpenes present in Plagiochila disticha (Plagiochilaceae) and Ambrosia peruviana (Asteraceae).
Aponte JC, Yang H, Vaisberg AJ, Castillo D, Málaga E, Verástegui M, Casson LK, Stivers N, Bates PJ, Rojas R, Fernandez I, Lewis WH, Sarasara C, Sauvain M, Gilman RH, Hammond GB.
Planta Med. 2010 May;76(7):705-7.
Theoretical analysis of the diradical nature of adenosylcobalamin cofactor-tyrosine complex in B12-dependent mutases: inspiring PCET-driven enzymatic catalysis.
Kozlowski PM, Kamachi T, Kumar M, Nakayama T, Yoshizawa K.
J Phys Chem B. 2010 May 6;114(17):5928-39.
Solution structure of the RBD1,2 domains from human nucleolin.
Arumugam S, Miller MC, Maliekal J, Bates PJ, Trent JO, Lane AN.
J Biomol NMR. 2010 May;47(1):79-83.
Selective inhibition of choline kinase simultaneously attenuates MAPK and PI3K/AKT signaling.
Yalcin A, Clem B, Makoni S, Clem A, Nelson K, Thornburg J, Siow D, Lane AN, Brock SE, Goswami U, Eaton JW, Telang S, Chesney J.
Oncogene. 2010 Jan 7;29(1):139-49.
Correcting for the Effects of Natural Abundance in Stable Isotope Resolved Metabolomics Experiments Involving Ultra-High Resolution Mass Spectrometry.
Hunter N.B. Moseley.
BMC Bioinformatics 2010, 11, 139-144.
Effects of introducing fibrinogen Aalpha character into the factor XIII activation peptide segment.
Jadhav MA, Isetti G, Trumbo TA, Maurer MC.
Biochemistry. 2010 Apr 6;49(13):2918-24.
FRET-like fluorophore-nanoparticle complex for highly specific cancer localization.
Wang J, Nantz MH, Achilefu S, Kang KA.
Adv Exp Med Biol. 2010;662:407-13.
Nucleophilic cationization reagents.
Biswas S, Huang X, Badger WR, Nantz MH.
Tetrahedron Lett. 2010;51(13):1727-1729.
Reevaluation of the phospholipid composition in membranes of adult human lenses by (31)P NMR and MALDI MS.
Estrada R, Puppato A, Borchman D, Yappert MC.
Biochim Biophys Acta. 2010 Mar;1798(3):303-11.
Size-dependent electrochemical oxidation of silver nanoparticles.
Ivanova OS, Zamborini FP.
J Am Chem Soc. 2010 Jan 13;132(1):70-2.
Multi-dimensional liquid chromatography in proteomics.
Zhang, X.; Fang, A.; Riley, C. P.; Wang, M.; Regnier, F. E. Buck, C.
Anal. Chimica Acta 2010, 664, 101-113.
Hunter N.B. Moseley, Lindsay J. Sperling, and Chad M. Rienstra.
J Biomol NMR accepted.
Counterion condensation and shape within poisson-boltzmann theory.
Lamm G, Pack GR.
Biopolymers. 2010 Mar 8 (Epub ahead of print).
Enabling individualized therapy through nanotechnology.
Sakamoto JH, van de Ven AL, Godin B, Blanco E, Serda RE, Grattoni A, Ziemys A, Bouamrani A, Hu T, Ranganathan SI, De Rosa E, Martinez JO, Smid CA, Buchanan RM, Lee SY, Srinivasan S, Landry M, Meyn A, Tasciotti E, Liu X, Decuzzi P, Ferrari M.
Pharmacol Res. 2010 Jan 5 (Epub ahead of print).
Asymmetric Oxygenation of a Ruthenium Dithiolate Mimics the Mixed Sulfenato/Sulfinato Donor Sets of Nitrile Hydratase and Thiocyanate Hydrolase.
Masitas CA, Mashuta MS, Grapperhaus CA.
Inorg Chem. 2010 May 20. (Epub ahead of print).
Resolution and characterization of the structural polymorphism of a single quadruplex-forming sequence.
Dailey MM, Miller MC, Bates PJ, Lane AN, Trent JO.
Nucleic Acids Res. 2010 Mar 25 (Epub ahead of print).
The Benefit of Hydrophobic Domain Asymmetry on the Efficacy of Transfection as Measured by in Vivo Imaging.
Nantz MH, Dicus CW, Hilliard B, Yellayi S, Zou S, Hecker JG.
Mol Pharm. 2010 Apr 9 (Epub ahead of print).
Lipids and the ocular lens.
Borchman D, Yappert MC.
J Lipid Res. 2010 Apr 20 (Epub ahead of print).
Self-calibrating microfabricated iridium oxide pH electrode array for remote monitoring.
Carroll S, Baldwin RP.
Anal Chem. 2010 Feb 1;82(3):878-85.
Trypanoside, anti-tuberculosis, leishmanicidal, and cytotoxic activities of tetrahydrobenzothienopyrimidines.
Aponte JC, Vaisberg AJ, Castillo D, Gonzalez G, Estevez Y, Arevalo J, Quiliano M, Zimic M, Verástegui M, Málaga E, Gilman RH, Bustamante JM, Tarleton RL, Wang Y, Franzblau SG, Pauli GF, Sauvain M, Hammond GB.
Bioorg Med Chem. 2010 Apr 15;18(8):2880-6.
Highly efficient Cu(I)-catalyzed synthesis of N-heterocycles through a cyclization-triggered addition of alkynes.
Han J, Xu B, Hammond GB.
J Am Chem Soc. 2010 Jan 27;132(3):916-7
Cytotoxic and anti-infective sesquiterpenes present in Plagiochila disticha (Plagiochilaceae) and Ambrosia peruviana (Asteraceae).
Aponte JC, Yang H, Vaisberg AJ, Castillo D, Málaga E, Verástegui M, Casson LK, Stivers N, Bates PJ, Rojas R, Fernandez I, Lewis WH, Sarasara C, Sauvain M, Gilman RH, Hammond GB.
Planta Med. 2010 May;76(7):705-7.
Theoretical analysis of the diradical nature of adenosylcobalamin cofactor-tyrosine complex in B12-dependent mutases: inspiring PCET-driven enzymatic catalysis.
Kozlowski PM, Kamachi T, Kumar M, Nakayama T, Yoshizawa K.
J Phys Chem B. 2010 May 6;114(17):5928-39.
Solution structure of the RBD1,2 domains from human nucleolin.
Arumugam S, Miller MC, Maliekal J, Bates PJ, Trent JO, Lane AN.
J Biomol NMR. 2010 May;47(1):79-83.
Selective inhibition of choline kinase simultaneously attenuates MAPK and PI3K/AKT signaling.
Yalcin A, Clem B, Makoni S, Clem A, Nelson K, Thornburg J, Siow D, Lane AN, Brock SE, Goswami U, Eaton JW, Telang S, Chesney J.
Oncogene. 2010 Jan 7;29(1):139-49.
Correcting for the Effects of Natural Abundance in Stable Isotope Resolved Metabolomics Experiments Involving Ultra-High Resolution Mass Spectrometry.
Hunter N.B. Moseley.
BMC Bioinformatics 2010, 11, 139-144.
Effects of introducing fibrinogen Aalpha character into the factor XIII activation peptide segment.
Jadhav MA, Isetti G, Trumbo TA, Maurer MC.
Biochemistry. 2010 Apr 6;49(13):2918-24.
FRET-like fluorophore-nanoparticle complex for highly specific cancer localization.
Wang J, Nantz MH, Achilefu S, Kang KA.
Adv Exp Med Biol. 2010;662:407-13.
Nucleophilic cationization reagents.
Biswas S, Huang X, Badger WR, Nantz MH.
Tetrahedron Lett. 2010;51(13):1727-1729.
Reevaluation of the phospholipid composition in membranes of adult human lenses by (31)P NMR and MALDI MS.
Estrada R, Puppato A, Borchman D, Yappert MC.
Biochim Biophys Acta. 2010 Mar;1798(3):303-11.
Size-dependent electrochemical oxidation of silver nanoparticles.
Ivanova OS, Zamborini FP.
J Am Chem Soc. 2010 Jan 13;132(1):70-2.
Multi-dimensional liquid chromatography in proteomics.
Zhang, X.; Fang, A.; Riley, C. P.; Wang, M.; Regnier, F. E. Buck, C.
Anal. Chimica Acta 2010, 664, 101-113.
2011 Faculty Favorite Awards
