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Denis F. Kinane, B.D.S., Ph.D.

Denis F. Kinane

Associate Dean for Research and Enterprise
Delta Endowed Professor
Director, Oral Health and Systemic Disease Research Group
Phone: 502-852-3175 Fax:502-852-4052


My research focuses on periodontal immune and inflammatory processes, mainly explaining the causes, development and susceptibility markers of periodontal disease. My research team also examine the relationship between oral and systemic health and diseases such as diabetes, cardiovascular disease and periodontal disease.


I am Associate Dean for Research at the University of Louisville, Kentucky and Endowed Professor of Periodontology and Professor of Immunology since April 2002. I lead a research group on Oral Health and Systemic Disease. I am the recipient of various grants from CDC, NIH and the PHS and our group's funding annually is around $4M. I have published over 200 scientific articles, and review scientific work for prestigious journals and international research bodies. I lecture regularly internationally and currently chair the Gordon Conference in Periodontology.

Recent Publications

  1. Eskan MA, Rose BG, Benakanakere MR, Lee MJ, Kinane DF. Sphingosine 1-Phosphate 1 and TLR4 Mediate IFN-{beta} Expression in Human Gingival Epithelial Cells. J Immunol. 2008;180(3):1818-25.
  2. Akridge M, Hilgers KK, Silveira AM, Scarfe W, Scheetz JP, Kinane DF. Childhood obesity and skeletal maturation assessed with Fishman's hand-wrist analysis. Am J Orthod Dentofacial Orthop. 2007 Aug;132(2):185-90.
  3. Kinane DF, Demuth DR, Gorr SU, Hajishengallis GN, Martin MH. Human variability in innate immunity. Periodontol 2000. 2007;45:14-34.
  4.  Onishi S, Honma K, Liang S, Stathopoulou P, Kinane D, Hajishengallis G, Sharma A. Toll-like receptor 2-mediated interleukin-8 expression in gingival epithelial cells by the Tannerella forsythia leucine-rich repeat protein BspA. Infect Immun. 2008 Jan;76(1):198-205. Epub 2007 Oct 29.
  5. Kinane DF, Galicia JC, Gorr SU, Stathopoulou PG, Benakanakere M. P. gingivalis interactions with epithelial cells.Front Biosci. 2008 Jan 1;13:966-84.
  6. Eskan MA, Hajishengallis G, Kinane DF. Differential activation of human gingival epithelial cells and monocytes by Porphyromonas gingivalis Fimbriae. Infect Immun. 2007;75:892-8.
  7.  Kinane DF, Mark Bartold P. Clinical relevance of the host responses of periodontitis. Periodontol 2000. 2007;43:278-93.
  8. Buduneli N, Buduneli E, Cinar S, Lappin D, Kinane DF. Immunohistochemical Evaluation of Ki-67 Expression and Apoptosis in Cyclosporin A-Induced Gingival Overgrowth. J Periodontol. 2007 78:282-89.
  9. Savarrio L, Donati M, Carr C, Kinane DF, Berglundh T. Interleukin-24, RANTES and CCR5 gene polymorphisms are not associated with chronic adult periodontitis. J Periodontal Res. 2007;42:152-158.
  10. Mäntylä P, Stenman M, Kinane D, Salo T, Suomalainen K, Tikanoja S, Sorsa T. Monitoring periodontal disease status in smokers and nonsmokers using a gingival crevicular fluid matrix metalloproteinase-8-specific chair-side test. J Periodontal Res. 2006 Dec;41(6):503-12.

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