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Thomas Knudsen

2011-2012 publications:

Knudsen TB and DeWoskin R (2011) Systems modeling in developmental toxicity. In: “Handbook of Systems Toxicology”, Edited: Daniel A. Casciano and Saura C. Sahu, John Wiley & Sons Limited Chichester, UK. (Chapter 37) pp 599-617.

Knudsen TB, Houck K, Sipes NS, Judson RS, Singh AV, Weissman A, Kleinstreuer NC, Mortensen H, Reif D, Setzer RW, Martin MT, Richard A, Dix DJ, and Kavlock RJ (2011) Activity profiles of 320 ToxCast™ chemicals evaluated Across 292 biochemical targets. Toxicology 282: 1-15.

Judson RS, Dix DJ, Kavlock RJ, Setzer RW, Cohen Hubal EA, Martin MT, Knudsen TB, Houck KA, Thomas RS, and Wetmore BA (2011) Estimating Toxicity-Related Biological Pathway Altering Doses for High-Throughput Chemical Risk Assessment. Chem Res Toxicol. 24: 451-462.

Chandler KJ , Barrier M, Jeffay S, Nichols H, Kleinstreuer N, Singh A, Reif D, Sipes N, Judson R, Dix D, Kavlock R, Hunter S and Knudsen T (2011) Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay. PLoS One. 6(6): e18540.

Martin MT, Knudsen TB, Reif DM, Houck KA, Judson RS, Kavlock RJ and Dix DJ (2011) Predictive model of reproductive toxicity from ToxCast high throughput screening. Biol Reprod. 85: 327-339.

Sipes NS, Padilla S and Knudsen TB (2011) Zebrafish – as an Integrative Model for 21st Century Toxicity Testing. Birth Defects Res C 93: 256-267.

Sipes NS, Kleinstreuer NC, Judson RS, Reif DM, Martin MT, Singh AV, Rountree MR, Dix DJ, Kavlock RJ and Knudsen TB (2011) Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data. Toxicol Sci 124: 109-127.

Knudsen TB, Kavlock RJ, Daston GP, Stedman D, Hixon M, and Kim J (2011) Developmental Toxicity Testing for Safety Assessment: New Approaches and Technologies. Birth Defects Res (Part B) 92: 413-420.

Kleinstreuer N, Judson R, Reif D, Sipes N, Singh A, Chandler KJ, DeWoskin R, Dix D, Kavlock R and Knudsen TB (2011) Environmental Impact on Vascular Development Predicted by High-Throughput Screening (HTS). Env Health Persp. 119: 1596-1603.

Kleinstreuer NC, West PR, Weir-Hauptman AM, Smith AM, Knudsen TB, Donley ELR and Cezar GG (2011) Predicting Developmental Toxicity of ToxCast Phase I Chemicals Using Human Embryonic Stem Cells and Metabolomics. Toxicol Appl Pharmacol 257: 111-121.

Green ML, Pisano MM, Prough RL, Singh AV and Knudsen TB (2011) Differential programming of p53 during rotenone-induced mitochondrial dysfunction. Toxicology 290: 31-41.

Judson RS, Mortensen H, Shah I, Knudsen T and Elloumi F (2011) Using Pathway Modules as Targets for Assay Development in Xenobiotic Screening. Molecular BioSystems 8: 531-542.

Hartung T, Blaauboer BJ, Bosgra S, Carney E, Coenen J, Conolly RB, Corsini E, Green S, Faustman EM, Gaspari A, Hayashi M, Hayes AW, Hengstler JG, Knudsen LE, Knudsen TB, McKim JM, Pfaller W and Roggen EL (2011) An Expert Consortium Review of the EC-commissioned Report “Alternative (Non-Animal) Methods for Cosmetics Testing: Current Status and Future Prospects – 2010”. ALTEX 28: 183-209.

Knudsen TB and Kleinstreuer NC (2011) Disruption of embryonic vascular development in predictive toxicology. Birth Defects Res C 93: 312-323.

Kleinstreuer NC and Knudsen TB (2011) Predictive Modeling and Computational Toxicology. In: Developmental and Reproductive Toxicology, A Practical Approach, Third Edition (Ed:  Ronald D. Hood), Informa Healthcare, London, UK. (Chapter 23) pp 578-591.

Martin MT, Knudsen TB, Judson RS, Kavlock RJ and Dix DJ (2012) Dashboard for Reproductive Toxicity Testing and Decision-Making. Systems Biol Reprod Med. 58: 3-9.

Basketter DA, Clewell H, Kimber I, Rossi A, Blaauboer B, Burrier R, Daneshian M, Eskes C, Goldberg A, Hasiwa N, Hoffmann S, Jaworska J, Knudsen TB, Landsiedel R, Leist M, Locke P, Maxwell G, McKim J, McVey  EA, Ouédraogo G, Patlewicz G, Pelkonen O, Roggen E, Rovida C, Ruhdel I, Schwarz M, Schepky A, Schoeters G, Skinner N, Trentz K, Turner M, Vanparys P, Yager J, Zurlo J and Hartung T (2012) t4 Report: A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing. ALTEX 29: 3-91.

Padilla S, Corum D, Padnos B,  Hunter DL, Beam A, Houck KA, Sipes NS, Kleinstreuer NC, Knudsen TB, Dix DJ, and Reif DM (2012) Zebrafish Developmental Screening of the ToxCast™ Phase I Chemical Library. Reprod Toxicol. 33: 174-187.

Barrier M, Chandler K, Jeffay S, Hoopes M, Knudsen T and Hunter S (2012) Mouse Embryonic Stem Cell Adherent Cell Differentiation and Cytotoxicity (ACDC) assay. Chapter, Springer Protocols (Humana Press) Methods in Molecular Biology – Developmental Toxicology (Eds:  J Hansen and C Harris). In Press.

Kavlock R, Chandler K, Dix D, Houck K, Hunter S, Judson R, Kleinstreuer N, Knudsen T, Martin M, Padilla S, Reif D, Richard A, Rotroff D and Sipes N (2012) Update on EPA’s ToxCast program: providing high throughput decision support tools for chemical risk management. Chemical Res Toxicol.  In Press.

Knudsen T, Martin M, Chandler K, Kleinstreuer N, Judson R and Sipes N (2012) Predictive Models and Computational Toxicology. In: Teratogenicity Testing: Methods and Protocols. Edited: P Barrow, Humana Press, New York. In Press.

States JC, Singh AV, Knudsen TB, Rouchka EC, Ngalame NO, Arteel GE, Piao Y and Ko MS (2012) Prenatal arsenic exposure alters gene expression in the adult liver to a proinflammatory state contributing to accelerated atherosclerosis . PLoS one. In Press.

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