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Manuel Casanova

Active grants: 2009-2013 – PI - Building a selective inhibitory tone in autism: an rTMS study.  RO1MH086784 $888,000.

2011-2012 publications:

Seelan RS, Pisano MM, Greene RM, Casanova MF, Parthasarathy R. Differential methylation of the gene encoding Myo-Inositol 3-phosphate synthase (Isyna1) in rat tissues. Epigenetics 3(1): 111-124, 2011.


Casanova MF, Williams EL. Prenatal Ultrasound: It’s Not Just a Photograph. Autism Science Digest, 1: 58-60, 2011.


Baruth JM, Williams EL, Sokhadze E, El-Baz A, Sears L, Casanova MF. Beneficial effects of repetitive Transcranial Magnetic Stimulation (rTMS) on behavioral outcome measures in autism spectrum disorder. Autism Science Digest, 1: 52-57, 2011.


Mott M, Fernandez-Bortran R, Casanova MF. Neuroinflammation in the pathogenesis of Autism Spectrum Disorders: converging evidence for systemic and central nervous system immune interaction. Brain Research Journal, 3(2): 1-31, 2011.


Casanova MF, El-Baz A, Switala AE, Williams EL, Williams, D, Minshew N, Conturo T. A quantitative analysis of the shape of the corpus callosum in autism. Autism, 15(2): 223-238, 2011.


Dombroski BA, Switala AE, El-Baz A, Casanova MF. Gyral Window mapping of typical cortical folding using MRI. Translational Neuroscience, 2(2): 142-147, 2011.


Williams EL, Casanova MF. Above genetics: lessons from cerebral development in autism. Translational Neuroscience, 2(2): 106-120, 2011.

Casanova MF, Starkstein S, Jellinger K. Clinicopathological correlates of behavioral and psychological symptoms of dementia. Acta Neuropathologica,       122(2): 117-135, 2011.


Vladimir B, Jaroslav B, and Casanova MF. Plausible mechanisms for brain structural and size changes in human evolution.  Collegium Anhropologicum 25(3):949-955, 2011.


El-Baz A, Elnakib A, Casanova MF, Gimel’farb G, Switala AE, Jordan D, Rainey S.  Accurate automated detection of autism related corpus callosum abnormalities.   Journal of Medical Systems, 35(5):929-939, 2011.


A. Elnakib, M. Casanova, G. Gimel’farb, A. Switala, and A. El-Baz, “Autism Diagnostics by Centerline-Based Shape Analysis of the Corpus Callosum,” Proc. of IEEE International Symposium on Biomedical Imaging: From Nano to Macro (ISBI'11), Chicago Illinois, USA,  March 30–April 2, 2011, pp. 1843-1846.


M. Nitzken, M. Casanova, G. Gimel’farb, F. Khalifa, A. Elnakib, A. Switala, and A. El-Baz, “3D Shape Analysis of the Brain Cortex with Application to Autism,”  Proc. of IEEE International Symposium on Biomedical Imaging: From Nano to Macro (ISBI'11), Chicago Illinois, USA, March 30–April 2, 2011, pp. 1847-1850.


M. Nitzken, M. Casanova, G. Gimel’farb, A. Elnakib, F. Khalifa, A. Switala, and A. El-Baz, “3D Shape Analysis of the Brain Cortex with Application to Dyslexia,”  Proc. of IEEE International Conference on Image Processing (ICIP'11), Brussels, Belgium, September 11-14, 2011, pp. 2713-2716.


Sokhadze G, Kaplan M, Edelson SM, Sokhadze EM, Baruth J, El-Baz A, Hensley MK, Casanova MF. Modulatory effects of ambient prism lenses on spatial attention in autism: an event related potential study. Journal of Neurotherapy 15(4):413-415, 2011.


Baruth J, Casanova M, Sears L, Sokhadze E. Transcranial magnetic stimulation (rTMS) modulates selective attention and executive functioning in autism. Journal of Neurotherapy 15(4): 431-432, 2011.


Sokhadze E, Baruth J, Sears L, Sokhadze GE, El-Baz A, Hensley M, Tasman A, Casanova MF. Event-related potential study of attention regulation in ADHD, Autism Spectrum Disorder, and Typical Children. Journal of Neurotherapy 15(4): 443-445, 2011.


Sokhadze E, Baruth J, Sears L, Sokhadze GE, El-Baz AS, Hensley M, Gross E, Tasman A, Casanova MF. Neuromodulation using rTMS improves error monitoring and correction function in autism spectrum disorders. Journal of Neurotherapy 15(4):445-447, 2011.


Casanova MF, Sokhadze E, El-Baz A, Baruth J, Mathai G, Sears L. Research at the University of Louisville Autism Center. Cutting Edge Therapies for Autism 2. Skyhorse Publishing, 425-429, 2011.


Baruth J, Sokhadze E. El-Baz A, Mathai G, Sears L, Casanova MF. Transcranial Magnetic Stimulation as a Treatment for Autism. Cutting Edge Therapies for Autism 2, 402-411, 2011.


M. Nitzken, M. Casanova, F. Khalifa, G. Sokhadze, and A. El-Baz, “Shape-Based Detection of Cortex Variability for More Accurate Discrimination Between Autistic and Normal Brains,”  In Handbook of Multi Modality State-of-the-Art Medical Image Segmentation and Registration Methodologies: Volume 2, Chapter 7, (A. El-Baz, R. Acharya, A. Laine, and J. Suri, Editors), Springer-Verlag, New York, March 2011, pp. 161-185. (ISBN: 978-1-4419-8203-2).


Casanova MF, El-Baz A, Switala A. Laws of conservation as related to brain growth, aging, and evolution: symmetry of the minicolumn. Frontiers in Neuroanatomy, 5:66, 2011.

Casanova MF, Mott M, Sokhadze EM. The neuropathology of autism: a review of the current literature.  The Siberian Journal of Special Education, 2, 2012.


Williams EL, El-Baz A, Nitzken M, Switala AE, Casanova MF. Spherical harmonics analysis of cortical complexity in autism and dyslexia. Transl Neurosci 3(1):36-40, 2012.


Sokhadze, E., Baruth, J.M., Sears, L.,  Sokhadze, G.E., El-Baz, A.S.,  and Casanova, M.F. Prefrontal Neuromodulation Using rTMS Improves Error Monitoring and Correction Function in Autism. Applied Psychophysiology & Biofeedback 37(2):91-102, 2012.


Gross E, El-Baz AS, Sokhadze GE, Sears L, Casanova MF. Sokhadze EM. Induced EEG gamma oscillation alignment improves differentiation between autism and ADHD group responses in a facial categorization task. J Neurotherapy, 16(2): 78-91. 2012.


Casanova MF, Baruth JM, El-Baz AS, Tasman A, Sears L, Sokhadze EM. Repetitive TMS (rTMS) modulates ERP indices of attention in autism. Translational Neuroscience, 3(2): 1-11, 2012.


Elnakib A, Casanova MF, Gimel’farb G, El-Baz A. Autism diagnostics by 3D shape analysis of the cropus callosum. In Kenji Suzuki (ed) Machine Learning in Computer-Aided Diagnosis: Medical Imaging Intelligence and Analysis. Medical Information Science Reference (an imprint of IGI Global) Hershey: Pennsylvania, ch. 15, pp. 315-335, 2012.


Sokhadze E, El-Baz A, Casanova MF. Event related potential study of attention regulation during illusory figure categorization task in ADHD, Autism Spectrum Disorder, and typical children. Journal of Neurotherapy, in press.


Williams EL, Casanova MF. Hyperlexia and dyslexia in autism:hitting a moving target. J Spec Ed Rehab, in press.


Abdelrahman M, Ali AM, Farag A, Casanova MF, Farag AA. New approach for classification of autistic vs. typically developing brain using white matter volumes. Computer and Robot Vision, in press.


Srivasta DP, Jones KA, Woolfrey KM, Burgdorf J, Russell TA, Kalmbach A, Lee H, Yang C, Bradberry MM, Wokosin D, Casanova MF, Seino S, Moskal JR, Waters J, Penzes P. Social, communication, and cortical structural impairments in Epac2-deficient mice. J Neuroscience, in press.

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