Research & Pilots


Project 1: Role of Dietary Fat in Alcoholic Liver Disease
Nutrient: Dietary Fat
PI: Craig J. McClain, MD
Project 2: HDAC Mediated Epigenetic Mechanisms in Alcohol-Induced Abnormal Gut-Liver Axis
Nutrient: Tributyrin and LGG
PI: Shirish S. Barve, PhD
Project 3: Sulforaphane-mediated epigenetic modulation of ethanol-induced apoptosis and teratogenesis
Nutrient: Sulfurophane and broccoli sprout extracts
PI: Shao-yu Chen, PhD
Project 4: Mechanisms of Alcohol-Induced Lung Disease
Nutrient: Amino acid Supplementation
PI: Jesse Roman, MD

Pilot Projects

The University of Louisville Alcohol Research Center (ULARC) was created to serve as a regional/national resource to investigate mechanisms of alcohol induced organ injury and to develop new agents/interventions to prevent/treat this organ injury, both of which represent important unmet research needs. The theme of the center is unique among alcohol centers: the role of nutrition in the development/progression of alcohol-induced organ injury. The Pilots Core will contribute to this program by funding new projects dedicated to this theme of research. We will do this by supporting young investigators, as well as recruiting established investigators, who propose projects that represent a change in direction for their research.

The ULARC is focused on nutrition and alcohol-induced organ injury. The ULARC is committed to providing new opportunities for pilot project funding to address the problems of nutrition:alcohol interactions. The goal of the Pilot Core is to provide support for promising clinical and translational research in alcohol-induced organ injury. This support will be targeted mainly at new investigators, those newly entering alcohol clinical and translational research, and alcohol clinical/translational investigators collaborating across departments and institutions. We will provide an environment that encourages development of pilot projects by providing alcohol researchers with the information, resources and mentoring needed to perform innovative clinical/translational research that meets the demands of 21st century science. In addition, we will improve the flow of information about existing and new opportunities and resources for pilot projects among University components and our affiliates. The ULARC will provide a clear entry point for investigators seeking to conduct alcohol research.

Requests for new pilot projects related to the alcohol/nutrition interactions will be announced as monies become available.