We are a research group interested in human genetics, human evolutionary history, and phylogeography. One of our main goals is to study genetic variation in human populations (past and present) to improve our knowledge of human health and human evolution.
Currently our studies are focused on three main areas:
- Cytokine polymorphisms, brain disorders, and evolution
- Cytokine polymorphisms in human populations
- Phylogeography of Tsuga canadensis (yes it's a tree...hey, we're multidisciplinary!)
Our group is committed to developing a program for training undergraduate and graduate students in the theory and methods of molecular anthropology.
- Christopher Tillquist, Ph.D., M.P.H. (Director). Associate Professor, Department of Anthropology and Research Associate, Department of Psychiatry and Behavioral Sciences.
- Fabian Crespo, Ph.D. Assistant Professor, Department of Anthropology.
- Manuel Casanova, M.D. Professor and Kolb Endowed Chair in Psychiatry, Deparment of Psychiatry and Behavioral Sciences.
- Allison Mann. Graduate Student
- Kara Keeton. Undergraduate
- Roxanne Leiter. Undergraduate
- Nicholas Short. Undergraduate
- Joanna Yun. Undergraduate with interests in population genetics of the Korean peninsula.
- Meghan Mott. Finished PhD in Anatomical Sciences and Neurobiology. Now post doc at the NIH.
- Rachel Hart. Undergraduate student in Biology. Off to medical school in Ohio. Go Rachel!
- Chandler Gatenbee. Finished MA in Anthropology at Utah, and is now back at U of L as PhD student of Paul Ewald in Biology. We're so proud!
- Brandy Schwallie (Technician Emerita).
At the University of Louisville
- Rafael Fernandez-Botran, Ph.D. Associate Professor, Department of Pathology and Laboratory Medicine
- Michael Perlin, Ph.D. Professor, Department of Biology
- Lonnie Sears, Ph.D. Associate Professor, Department of Pediatrics
- Cytokine polymorphisms, neuroinflammation and brain disorders
- One area where neurobiology and immunology overlap is the biology of cytokines. The brain is now seen as capable of responding and/or influencing the immune response. The basis for cytokine involvement in multiple general medical illness such as type 1 diabetes mellitus, rheumatoid arthritis, and asthma is very well known. Now, growing evidence is showing that we must include on this list different neuropsychiatric conditions such as multiple sclerosis, Parkinson's disease, schizophrenia, autism, Alzheimer's disease and major depression. Currently, we are studying different cytokine polymorphisms (CP) and their potential association with autism, progressive supranuclear palsy, and Alzheimer's disease.
- Cytokine Polymorphisms in Human Populations:
- It has been known for some time that cytokines and their receptors are often encoded by highly polymorphic genes, and these polymorphisms may be responsible for observed inter-individual differences in cytokine production. However, few studies have been conducted to analyze the cytokine polymorphism (CP) distribution in different human populations. This research will allow us to estimate the distributions of different cytokine alleles and establish the potential usefulness of cytokine polymorphisms as potential markers for future studies of health significance.
- Phylogeography of Tsuga canadensis
- Using samples collected throughout North America, we are sequencing several loci in order to better understand the phylogeographic distribution of genetic variation of the Canadian hemlock. As I write, this tree is being decimated by the wooly adelgid.
Past research endeavors of the MAPS Group
- Frankfort Cemetary Project: An ancient human DNA study
- The Frankfort Cemetary Project is a cultural resource management effort by the Kentucky Archaeological Survey to document materials and remains found in a 19th century cemetary in Frankfort, Kentucky. One of three early cemetaries, this particular cemetery is a bit of a black box, as there are almost no records. Through the analysis of mitochondrial DNA recovered from teeth, we were able to provide information about the population history of the area. We established that, at least according to the sampled mitochondrial matrilines, there were African and non-African individuals buried in the cemetary, thus leveraging the anthropometric information collected. In several cases involving juvenile remains, a mitochondrial haplogroup was able to provide some information where traditional anthropometrics were not sufficient. The results of this project were presented at the annual meetings of the American Association of Physical Anthropologists (Anchorage, Alaska 2006) and the Society for American Archaeology (San Juan, Puerto Rico, 2006). Having submitted a report to KAS, we are working feverishly on the final manuscript.
We are always interested in the possibiltiy of incorporating new undergraduate and graduate students in our laboratory. Please contact one of us if you are interested in training and working in the lab. Click here for details concerning the guidelines of the Undergraduate Research Training in Molecular Anthropology (URTMA).